CORM iCORM

For a long time, the inactivity of iCORM-3 was associated with its inability to produce COMb when incubated with deoxy-Mb in the Mb assay (the Mb assay quantifies the CO released by a CORM to deoxy-Mb see Section 4.1), which CORM-3 did very rapidly (fast CO releaser). The latter observation was recently... 

The interaction with proteins such as semm albumin and transferrin also explains why CORM-3 does not raise the values of COHb in systemic circulation at therapeutic doses, which is one of the most welcome characteristics of the in vivo therapy with CORM-3 [73, 83]. In fact, after the loss of one CO as CO2, the resulting c -Ru (CO)2 fragments are very slow CO releasers, similar to iCORM-3, which is an unidentified mixture containing such species [78],... 

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