Corey-Chaykovsky reaction dimethyloxosulfonium methylide

The most commonly used reagents to effect the addition of a methylene group to an aldehyde or ketone are sulfur ylides such as dimethylsulfonium methylide (1) or dimethyloxosulfonium methylide (2) (Corey-Chaykovsky reaction). This reaction is well reviewed in standard treatises of organic synthesis - and several useful monographs. - This update will concentrate on progress attained from 1975. The reader is also encouraged to consult reviews on the chemistry of the related sulfoximine-derived ylides such as (3). -"... 

An interesting variation of the aza-Corey-Chaykovsky reaction provides a pathway to difluoromethyl-substituted aziridines. Reduction of trifluoromethylimine 143 with magnesium in the presence of chlorotrimethylsilane gave the enamine 144. Treated with dimethyloxosulfonium methylide in DMSO, 144 hrst underwent desilylation and tautomerization to produce imine 145, which then afforded aziridine 146 via the aza-Corey-Chaykovsky reaction in 92% yield. 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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