Nonflat Cores

As another subset of our approach, we chose a few known nonflat cores and enumerated them with derived fragments. These cores were subjectively selected from known drugs and literature. The list used below for this exercise is not exclusive and can be expanded based on requirements [18,19]. The nonflat cores are depicted in blue. Typically, they have more than one point of diversification. For ease of handling, we fixed one diversification point with a commonly found hydrophobic (hp) group (hp = fluorophenyl, cylopropyl, etc.). The other diversification point was used for coupling with the aforementioned daughters. 

Nonflat core in which active core height is similar to or larger than core equivalent diameter... 

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