Coregulator-Based Mechanisms of SERM Estrogen-Like Action

Coregulator-Based Mechanisms of SERM Estrogen-Like Action 

for effective gene transcription, programmed and targeted by the shape and phosphorylation status of ER and coactivators, a dynamic and cyclic process of transcription complex assembly [255] and destruction of transcription complexes by the proteasome is required. Estrogen- and SERM-receptor complexes have differing accumulation patterns in the target cell nucleus [151, 256] primarily because the relative rates of destruction of the complexes are different [251]. 

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