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Copper Clip-Phen

B. Copper Clip-Phen B.l. Design of Clip-Phen... [Pg.89]

Cl oxidation has been observed with many other DNA oxidizing agents such as y-radiolysis, neocarzinostatin, Mn-TMPyP (4,5,7), copper complexes of benzosulfonamides (40), Cu-kanamycin (41), or for copper complexed to guanine of DNA (42), but it was not associated to direct strand-cleavage events except for metal complexes like Cu(3-Clip-Phen) (43), or Ru(terpyridine)(bipyridine) complexes (44). [Pg.83]

Unfortunately, copper complexes of Clip-Phen seemed to be able to adopt different geometries and stoichiometries in solution with the predominant presence of monomeric LCu species. Consequently their physico-chemical characterization was found difficult. [Pg.90]

Since activated Cu(3-Clip-Phen) cleaves DNA without clear sequence selectivity it is the ability of the copper complex of the conjugate of 3-Clip-Phen with the distamycin analogue to produce, after activation, sequence selective DNA cleavage that allowed easier confirmation of these... [Pg.92]

See other pages where Copper Clip-Phen is mentioned: [Pg.77]    [Pg.77]    [Pg.82]    [Pg.89]    [Pg.90]    [Pg.90]    [Pg.91]    [Pg.92]    [Pg.114]    [Pg.1603]   


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