Copper-Catalyzed Synthesis of Oxindoles

The intramolecular synthesis of 3,3-disubstituted oxindoles through C(sp )-H and Ar-H coupling of anilides using potassium t-butoxide as base and stoichiometric Cu(0Ac)2 H20 in DMF (N,N-Dimethylformamide) was reported by Taylor et /.[66]. This reaction also could be conducted under catalytic Cu(0Ac)2-H20 in toluene or mesitylene with atmospheric oxygen as the reoxidant without an additional base. A range of substrates including several 

Recently, another novel reaction for the synthesis of trifluoromethylated oxindoles via Cu(N03)2-2.5H20-catalyzed aryl C(sp )-H functionalization was described by Liang, Lipshutz, and coworkers. The trifluoromethylated oxindoles 

Af-alkyl-Af-phenylacrylamides and aryl aldehydes undergo oxidative cascade coupling reaction to 3-(2-oxo-2-arylethyl)mdolin-2-ones in good yields using CUCI2/TBHP as catalyst and oxidant, respectively. Both the C(sp2)-H of the Af-alkyl-Af-phenylacrylamides and C(sp )-H bonds of the aldehyde were activated in one step under this oxidative system. The acyl radical which is generated from 

Copper-Catalyzed Synthesis of lndole-2,3-dione (Isatins) 

Ilangovan and Satish reported that tertiary amines can also be used for the synthesis of isatins under Cu(0Ac)2-H20, NaOAc, and air system at relatively lower 

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