Copper catalysts Friedel-Crafts addition

Pseudo-C3-symmetrical trisoxazoline copper(II) complexes prove to be excellent catalysts in the Friedel-Crafts alkylation of indoles with alkylidene malonates (Eq. 7.13). Water tolerance of chiral catalyst trisoxazoline/Cu(OTf)2 was examined, and it was found that the addition of up to 200 equivalents of water relative to the catalyst in /,vo-butyl... 

The Friedel-Crafts reaction of electron-rich aromatic and heteroaromatic compounds with carbonyl acceptors is one of the fundamental reactions for forming carbon-carbon bonds. In recent years, several enantioselective approaches have been described utiMzing copper and scandium complexes as catalysts. In addition, the use of organocatalytic approaches has been considerably expanded. 

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