Hydroamination Cope-type

Brown, A. R. Uyeda, C. Brotherton, C. A. Jacobsen, E. N. Enantioselective thiourea-catalyzed intramolecular cope-type hydroamination, 7 Am. Chem. Soc. 2013,135, 6747-6749. 

This is a consequence of advantageous formation of a mixed aminal intermediate, which is able to undergo intramolecular Cope-type hydroamination, thereby leading to high yield of the required hydroamination product (Scheme 2). ... 

Another enantioselective hydroamination of this type was attained via the transient formation of aminal (37) from its precursors, namely hydroxylamine (34) and amine (35), in the presence of the chiral aldehyde (36) as catalyst. The vicinal diamines (38) thus obtained were of <97% This retro-Cope chemistry, in particular the concept... 

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See also in sourсe #XX -- [ ]

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