Conversion into gallic acid

In India, hoth synthesis of 3,4,5-TMBA and its conversion into Trimethoprim have heen carried out during the last two decades. M/s. Inventaa, Hyderabad produce almost 50 tpm or 600 tpa of 3,4,5-TMBA. Zora Pharma, Ahmedabad used to produce 25 tpm or 300 tpa of the material. Both Inventaa and Zora 3,4,5-TMBA production were based on p-cresol. One Bombay based drug co., namely. Alpha Drugs, produces TMBA from gallic acid imported from China. Indian production of 3,4,5-TMBA is estimated to the tune of 1200 tpa. Most of this quantity is captively consumed to make trimethoprim. However, some quantities of TMBA (300-400 tpa) are exported mostly to W. Europe. 

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