Convergent chemoenzymatic synthesis

Unusual transglycosylation activity of flavobacterium meningosepticum endogjycosidases enables convergent chemoenzymatic synthesis of core fucosylated complex N-gJycopeptides. ChemBioChem, 12, 932-941. 

Orru, R.V.A., Mayer, S.F., Kroutil, W. and Faher, K., Tetrahedron, Chemoenzymatic deracemi-sationof (+)-2,2-disubstituted oxiranes. 1998, 54, 859. Steinreiber, A., Hellstrdm, H., Mayer, S.F., Orru, R.V.A., Faber, K., Chemo-enzymatic enantio-convergent synthesis of C4-huilding blocks containing a fully substituted chiral carbon center using bacterial epoxide hydrolases. Synlett, 2001, 111. 

Another example of an enantioconvergent transformation of racemic epoxides was reported by Faber and coworkers who employed a chemoenzymatic approach for the synthesis of optically enriched diols. They used an (S)-selective epoxide hydrolase from Nocardia sp. in connection with an add catalyzed hydrolytic step to convergently prepare (S)-diols 41 in good to excellent yields (71-98%) with enantiomeric excess values up to 99% (Scheme 9.13) [75]. 

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