Controlled progressive freezing

Response fluctuations occur with disease progression as the patient s dopamine reserves are depleted in the brain and as a complication of PD treatment. Motor fluctuations include delayed peak response, early wearing off, random unpredictable on-off, and freezing. Dyskinesias include chorea, dystonia, and diphasic dyskinesia. Wearing off can be visualized by imagining the therapeutic window of dopamine narrowing over time. The therapeutic window is defined as the minimum effective concentration of dopamine required to control PD symptoms (on without dyskinesia) and the maximum concentration before experiencing side effects from too much dopamine (on with dyskinesia). Early in the disease, a dose of... 

Today, most freeze-drying processes are operated by data developed in a pilot plant and qualified in the production plant The process supervision is based on time-con-trolled temperatures and pressures. TLC uses data measured during the process to control and document its progress as given in Table 2.6. 

Freeze-Thaw, Vacuum Drying (1A, IB). The frozen books were laid with the spine vertical on metal shelves inside a large chamber. A controlled amount of heat was applied to the shelves to thaw the ice and to allow the water to evaporate. A vacuum was established to remove the water from the books. Progress in removing water from the books was checked by noting the return of the book s weight to its original value. 

The convulsions progress, increasing in intensity and frequency until the backbone arches continually. Death comes from asphyxiation caused by paralysis of the neural pathways that control breathing, or by exhaustion from the convulsions. The subject usually dies within 2-3 h after exposure. At the point of death, the body freezes immediately, even in the middle of a convulsion, resulting in instantaneous rigor mortis. 

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