Contrast media premedication

Prior interleukin-2 therapy can induce atypical contrast medium hypersensitivity in the form of toxic recall reactions of various types (SEDA-17, 537), and these cannot be prevented by glucocorticoid premedication (315). 

The use of premedication with steroids and Hi and Hg histamine receptor blockers can significantly reduce the adverse reactions to high osmolality contrast media. There are suggestions to extend their use to modify even the reactions to low osmolality contrast media. Pretesting of contrast media reactors by injecting 1 mL of the nonionic contrast medium has also been reported (539). 

Davenport MS, Cohan RH, Caoili EM, Ellis JH. Repeat contrast medium reactions in premedicated patients frequency and severity. Radiology 2009 253(2) 372-9. 

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