Continuous Separation of Stereoisomers

Goals Kinetic separation of isomers by crystal growth of the desired isomer on a seed bed of that isomer (desired all-growth process) 

Robust continuous process applicable to selective crystallization in general 

Issues Minimize nucleation of undesired isomer—strict control of supersamration. 

Maintain particle balance—create new growth centers in the absence of nucleation. 

This process is outlined here as an example of the use of tightly controlled supersamration in a cooling crystallization. It is discussed in greater detail in Example 11-6. 

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