Contents Reverse Genetics

Leptin administratioii suppresses hypothalamic endocannabinoid levels in normal rats, while genetically obese, chronically hyperphagic rodents express leptin-reversible, elevated hypothalamic anandamide and 2-AG levels (J9). Moreover, fasting seems to inaease levels of both anandamide and 2-AG in the limbic forebrain and, to a lesser extent, of 2-AG in the hypothalamus, whereas in fed animals the hypothalamic content of 2-AG declines (72). However, another study has shown that while food deprivation failed to alter anandamide levels in whole brain, hunger did increase intestinal anandamide content, which normalized following feeding (79). 

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