Conservation of dinuclear metal centers in ferritins

The vast majority of studies of iron storage mechanisms have been carried out in vitro [1, 2], From this research it has generally been agreed that the protein shell of 

Superscript numbers represent the numbers of known sequences having identical dinuclear site res-  

Numbers are Ca root mean square deviations (A) of superposed four-helix bundles of F-B-R proteins, with numbers in parentheses corresponding to the eight diiron center residues (27, 34, 61, 62, 65, 107, 141 and 144-HuHF numbers). 

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