Conjugation of glutathione

The glutathione S-transferases (GST) enzymes are dimeric enzymes that catalyze the conjugation of glutathione (GSH) to electrophilic xenobiotics in order to inactivate them and facilitate their... 

Boyland, E. and Chasseaud, L.F., Enzyme-catalysed conjugations of glutathione with unsaturated compounds, Biochem. ]., 104, 95,1967. 

Figure 13.32. Major reactions of conjugation of glutathione, sometimes accompanied by a redox reaction.

B35. Bolton, M. G., Colvin, O. M., and Hilton, J., Specificity of isozymes of murine hepatic glutathione S-transferase for the conjugation of glutathione with L-phenylalaline mustard. Cancer Res. 51, 2410-2415 (1991). 

Robertson, I. G. C., Guthenberg, C., Mannervik, B., and Jernstrdm, B., Differences in stereoselectivity and catalytic efficiency of three human glutathione transferases in the conjugation of glutathione with 7p-,8a-dihydroxy-9a,10a-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene. Cancer Res. 46, 2220-2224 (1986). 

Robertson, 1. G. C, and JemstrSm, B., The enzymatic conjugation of glutathione with bay-region diol-epoxides of benzo(a)pyFene, benz(a)anthracene and chrysene. Carcinogenesis (London) 7, 1633-1636 (1986). 

Cox, R.H., 0. Hj nandez, B. Yagen, B. Smith, J.D. McKinney, and J.R. Bend, C NMR Studies of the Structure and Stereochemistry of Products Derived from the Conjugation of Glutathione with Alkene and Arene Oxides. In Environmental Health Chemistry. The Chemistry of Environmental Agents as Potential Human Hazards, J.D. McKinney (ed.), Ann Arbor Science Publishing Co., Ann Arbor, Michigan, 1980, Chapter 20. 

Hernandez, 0., M. Walker, R. Cox, G.L. Foureman, B. Smith, and J.R. Bend, Regioselectivity and Stereospecificity in the Enzymatic Conjugation of Glutathione with (+) Benzo(a)pyrene... 

Dean IV, Devarenne TP (1997) Peroxidase-mediated conjugation of glutathione to unsaturated phe-nylpropanoids. Evidence against glutathione S-transferase involvement. Physiol Plant 99 271-278... 

L. F. Chasseaud, The nature and distribution of enzymes catalyzing the conjugation of glutathione with foreign compounds. Drug Metab. Rev. 2, 185-220 (1973). 

Sims and Grover (1965) concluded that the enzyme from rat liver which catalyzes the conjugation of glutathione with a-3,4,5, -tetra-cyclohexeiie and 7-2,3,4,5,C-pentachlorocyclohexene is the iS-arj l-transferase. Chlorooyclohexane and hexachlorocjmlohexane were not substrates. 

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