Conjugate addition reactions organometallic reagents

Deprotonation of the vinylic proton is a serious side-reaction in the conjugate addition of organometallic reagents to y-siloxy-a, /J-unsaturated sulfones (89)63b. The use of the... 

Another very important method for specific enolate generation is the conjugate addition of organometallic reagents to enones. This reaction, which not only generates a specific enolate, but also adds a carbon substituent, is discussed in Section 8.1.2.3. 

The conjugate addition of organometallic reagents to a./i-unsaturated compounds is one of the basic methods in our repertoire for the construction of carbon-carbon bonds. These addition reactions have been used as key steps in the synthesis of numerous biologically active compounds, and show a broad scope due to the large variety of donor and acceptor compounds that can be employed. It is evident that a tremendous effort has been devoted over the last three decades to develop asymmetric variants of this reaction. ... 

Reactions that result in the formation of C C bonds are of central importance in the construction of organic molecules. One such reaction is the conjugate addition of organometallic reagents to a,/3-unsaturated carbonyl... 

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