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Conjugate addition anion-stabilizing substituents

One trick to persuade a stubborn enolate to do conjugate rather than direct substitution is to add an extra anion-stabilizing substituent in the a position. The margin shows a selection of reagents that do this. In each case the extra group (COjEt, SPh, SOPh, S02Ph, SiMej, and Br) can be removed after the conjugate addition is complete. [Pg.610]

More generally, many combinations of EWG substituents can serve as the anion-stabilizing and alkene-activating groups. Conjugate addition has the potential to form a bond a to one group and (3 to the other to form a a,y-disubstituted system. [Pg.183]

See other pages where Conjugate addition anion-stabilizing substituents is mentioned: [Pg.189]    [Pg.757]    [Pg.757]    [Pg.757]    [Pg.26]    [Pg.757]    [Pg.121]    [Pg.780]    [Pg.780]    [Pg.188]    [Pg.258]    [Pg.118]    [Pg.21]    [Pg.181]    [Pg.558]    [Pg.84]    [Pg.146]    [Pg.261]    [Pg.789]    [Pg.169]    [Pg.715]    [Pg.789]    [Pg.90]    [Pg.246]   


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Anion stabilization

Conjugated stability

Conjugation substituents

Stabilization conjugative

Stabilizers additives

Stabilizing additives

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