Congenital aromatase deficiency

Several clinical issues have already been alluded to. The first issue is congenital aromatase deficiency. Serious cases in adults appear to be relatively rare - and have been treated with estrogen replacement therapy . However, some children are considered to have attenuated P450 19A1 activity. ... 

Herrmann, B.L., B. Sailer, O.E. Janssen, P. Gocke, A. Bockisch, H. Sperling et al. (2002). Impact of estrogen replacement therapy in a male with congenital aromatase deficiency caused by a novel mutation in the CYP19 gene. J. Clin. Endocrinol. Metab. 87, 5476-5484. 

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