Conformations, synthesized oligosaccharides

In 2012, Lemau de Talance et al. synthesized a galactoside 106 locked in a boat conformation as template for artificial lectins (Fig. 31). Pyranoses, expressed as mono- and oligosaccharides, usually adopt in their ground state conformation a chair (C) conformation. However, there are few examples of natural or synthetic sugars possessing less populated conformations in their bioactive form or at the transition state, as the boat (B), the skew-boat (S) or the half-chair conformation (H 32a,50,103,137 (-] g importance of carbohydrates in many bio-... 

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