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Conformational Selection Using a 3,5-O-Di-tert-Butylsilylidene Protecting Group

7 Conformational Selection Using a 3,5-O-Di-tert-Butylsilylidene Protecting Group [Pg.112]

Computational studies indicated that the arabinofuranosyl oxocarbenium ion can be locked in the E3 conformation by employing a 3,5-O-di-tert-butylsilylidene (3,5-0-DTBS) protecting group, which places 03 and 05 in a pseudoequatorial [Pg.112]

SCHEME 4.15 Securing of the E, conformer using the 3,5-O-DTBS protecting group to ensure 1,2-cfs-glycosylation. [Pg.113]




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A protective group

Conformal groups

Conformation selection

Conformational selection

Group selectivity

Groups, use

O selective

O-protection

O„ groups

Protective groups selection

Protective groups selective

Selection group

Selective protection

Tert group

Use as protecting groups

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