Conformational hypothesis

Paclitaxel and Related Molecules. The Single Conformer Hypothesis... 

Rezai, T., et al. Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers. J. Am. Chem. Soc. 2006, 128, 2510-2511. 

Nukada T, Berces A, Wang L, Zgierski MZ, Whitfield DM (2005) The two-conformer hypothesis 2, 3, 4, 6-tetra-O-methyl-mannopyranosyl-and glucopyranosyl oxocarbenium ions. Carbohydr Res 340 841-852... 

Examination of the possible conformational models indicated that the Met-4 and Gly-10 residues were in reasonable proximity. We therefore decided to prepare a cyclic analog to test our conformational hypothesis. For this purpose we prepared [Cys Cys ]-a-MSH (9, Table 2) in which the Met-4 (-CH2-CH2-S-CH3) and Gly-... 

We have previously reported (19) the electronic and vibrational spectra, solution viscosity and electronic properties of PANI-EB and PANI-ES in HFIP solvent. We are able to correlate Ae change in hydrodynamic volume with a concomitant red shift in the UV-Vis / near IR spectra and thus verify the coil to expanded coil conformation hypothesis (20). We have also found that high quality films can be cast from HFIP that are relatively solvent free, free standing and exhibit high electrical conductivities which depends on which dopant is used. However, not matter what solvent is used, pure polyaniline films are quite brittle and lack the physical properties necessary for many applications. 

One piece of experimental data embraced by the conformational hypothesis is the finding that the major energy requirement in the formation of ATP is for dissociating the ATP bound to the enzyme active site, and not for actually forming the covalent bond between ADP and Pi (Boyer, 1977, Slater, 1977). 

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