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Conformational changes limited range

Interesting kinetic behavior is found for the adduct formation of 7-lysozyme-substituted 4-nitrobenzofurazan with OH , the attack involving the phenolic hydroxyl group of Tyr-23 of lysozyme.211 In the pH range 10.5-12.7 the formation of adduct 203 is markedly faster than that of adducts such as 204 obtained from nonproteic model compounds. The difference is attributed to a preliminary ionization of the distantly located OH of Tyr-20, followed by a rate-limiting conformational change and, finally, by a fast attack of OH. The OH nucleophile is believed to react much more... [Pg.443]

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See also in sourсe #XX -- [ Pg.311 , Pg.350 ]



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Conformational limitations

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