Conformational aspects diagrams

Fig. 8.12B. Structure of c-Src kinase phosphorylated at Tyrosine 527. Ribbon diagram showing the structure and organization of the closed conformation" of c-Src kinase. Two aspects of the structure are important for the regulation of c-Src kinase i) The phosphorylated Tyr 527 of the C-terminal tail is engaged in an intramolecular interaction with the SH2 domain, ii) The SH3 domain binds to the linker between the SH2 domain and the kinase domain. Both interactions are assumed to fix an inactive state of the kinase.

A schematic perspective drawing 53 is particularly useful, with a view from the side and somewhat above the plane, to avoid overlap of atoms. This is usually a version of the true perspective drawing that a computer might produce, modified to clarify significant aspects of the conformation. Models help. The diagrams 51-53 illustrate the preferred conformation of cyclododecane in these conventions... 

The mathematical aspects developed above can be summarised as follows. Whenever a nido polyhedron with C y (n > 3) symmetry is generated from a closo deltahedron it will have a non-bonding e set of molecular orbitals. This e set is localised predominately on the open face of the polyhedron and the n and components conform to the vector diagrams shown in Figs. 19 and 22. If this e set is filled, then the nido polyhedron is characterised by n -I- 2 skeletal electron pairs. 

Figure 8 provides the most comprehensive and direct comparison of this theory with experiment [63]. The upper panel is the NSCFT diagram for conformationally symmetric diblocks, and the lower panel is the diagram constructed for PS-PI from experiment. In this constmction, the dots represent the observations, and lines are added as visual aids. There are numerous aspects of agreement between the theory and experiment. The stable ordered phases are the L, G, C, and S, and no others. 

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