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Conformation of chlorpromazine

Figure 15. One of a family of conformers of chlorpromazine fit within limits criteria for the neuroleptic receptor. Shown in two orthogonal views aligned with apomorphine (---------------). Nitrogen position indicated by arrows. Figure 15. One of a family of conformers of chlorpromazine fit within limits criteria for the neuroleptic receptor. Shown in two orthogonal views aligned with apomorphine (---------------). Nitrogen position indicated by arrows.
Fig. 22.5. Conformations of chlorpromazine (A), dopamine (B), and their superposition (C) as determined by x-ray crystallographic analysis. The a, b, and c in (A) designate rings. Also shown (D) is another conformation in which the alkyl side chain of chlorpromazine is in the trans conformation (ring a and amino side chain), which is not superimposable on to dopamine. (Adapted from Horn AS, Snyder SH. Chlorpromazine and dopamine Conformational similarities that correlate with the antischizophrenic activity of phenothiazine drugs. Proc Natl Acad Sci U S A 1971 68 2325-2328 with permission.)... Fig. 22.5. Conformations of chlorpromazine (A), dopamine (B), and their superposition (C) as determined by x-ray crystallographic analysis. The a, b, and c in (A) designate rings. Also shown (D) is another conformation in which the alkyl side chain of chlorpromazine is in the trans conformation (ring a and amino side chain), which is not superimposable on to dopamine. (Adapted from Horn AS, Snyder SH. Chlorpromazine and dopamine Conformational similarities that correlate with the antischizophrenic activity of phenothiazine drugs. Proc Natl Acad Sci U S A 1971 68 2325-2328 with permission.)...
See other pages where Conformation of chlorpromazine is mentioned: [Pg.219]    [Pg.485]    [Pg.493]   
See also in sourсe #XX -- [ Pg.9 ]



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