Compound selection fractional factorial

Figure 3. The substituents Rl, R2 and R3 can be selected using a fractional factorial design (FFD). Firsts, the eight substituents candidates were plotted on a 2D space of PPs (p, and p2) and four representatives (A, ++ B, —t F, — H + -) were extracted. Then, these were combined according to the FFD scheme to obtain a series of eight compounds.

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