Compliance implantation therapy

One factor to keep in mind when evaluating disulfiram is that its effects may be enhanced considerably if its u.se is combined with a behavioral program that in part consists of supervised administration of the disulfiram (e.g., by the patient s spouse) to the patient (Hughes Cook, 1997). This apparently addresses a major practical problem with using disulfiram clinically It typically requires daily administration of the prescribed dose, and patients tend to show poor compliance with such a regimen. Disulfiram implants have been tried as another w ay to solve the compliance problem, but their effectiveness has not been shown clearly, and the bioavailability of the implanted disulfiram has not been demonstrated in clinical trials. Additional well-controlled studies of supervised disulfiram therapy would allow us to specife the conditions under which its administration is most likely to enhance outcomes. 

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