Non-covalent complexes

As pointed out in Chapter 1, chemistry has just entered the confines of the supramolecular world and great feats in synthetic power for the elaboration of ever more complex non-covalent architectures lie ahead, just as there has been a rich and exciting but long way of tribulations from the synthesis of urea in 1828 to those of vitamin B12 [1.3, 1.4], palytoxin [9.177a], or calicheamicin [9.177b], to cite just a few major achievements in recent times [9.177c]. 

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