Complexes Comprehensive Organic Functional Group

Applications of IBX in organic synthesis have been summarized in several comprehensive reviews [1105, 1106], IBX is a particularly useful oxidant for the selective oxidation of alcohols to carbonyl compounds, even in complex molecules in the presence of other functional groups. Primary alcohols are oxidized by IBX in DMSO to the corresponding aldehydes at room temperature without overoxidation to the acids. The chiral primary alcohols are oxidized without epimerization and various functional groups like thioethers, amines, carboxylic acids, esters, carboxamides and both conjugated and isolated double bonds are compatible with IBX [1132,1133]. Several representative examples of alcohol oxidations using IBX in DMSO are shown below in Schemes 3.330-3.335. 

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