Complexation actinocin derivatives

With an aim to investigate the molecular mechanisms of actinocin derivatives complexation in water solution, the molecular dynamics simulation of both monomer and dimer forms of the ligands was carried out [90]. The hydration properties... 

The second step in the investigation of the activity of new synthetic anticancer antibiotics (actinocin derivatives) at the molecular level is a detailed study of their complexation with DNA. 

Some pecnliarities of the heat absorption curves eaused by melting of DNAs having different nucleotide compositions were observed for the solutions of flee DNA and its complexes with actinocin derivatives Actll-ActV Notably, for the DNA-Actll complex the heat absorption curve is signifieantly distorted in high-temperature area when the GC-rieh blocks of DNA are melted. 

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