Competitive-less inhibition

Competitive-less inhibition (Fig. 14.2, d) the inhibitor forms an inactive complex with the enzyme-substrate complex... 

Fig. 14.2. Graphical representation of different inhibitirai mechanisms a, ncm-competitive b, competitive c, mixed and d, competitive-less inhibition.

Scavengers Inhibit nitrosamine formation by competing with the amine for the nltrosatlng agent. Ascorbic acid Is a typical exan le of the competition by rapid reduction of the nltrosatlng agent as shown. 

Fleet GWJ, Nicholas SJ, Smith PW, Evans SV, Fellows LE, Nash RJ. (1985) Potent competitive inhibition of a-galactosidase and a-glucosidase activity by l,4-dideoxy-l,4-iminopentitols Synthesis of l,4-dideoxy-l,4-imino-D-lyxitol and of both enantiomers of l,4-dideoxy-l,4-iminoarabinitol. 

Competitive inhibition can be reversed by increasing the concentration of substrate and letting Le ChStelier s principle operate. This is illustrated by the following equilibria that would exist in a solution containing enzyme (E), substrate (S), and competitive inhibitor (1) ... 

Nous avons 6tabli (14) que I hydroxylamine (5 X 10 10 M), pr4inoub6e avec les preparations de tissus, produit (avec des concentrations moderees de cetoacides) une inhibition competitive assez accentuee des reaction de transamination. 

A system which is depending on adsorption onto sites of the type described in Section IV, B, 2, b is open to competitive inhibition by solutes, generally of analogous structure, who show for the same site specific affinities which often depend on very small structural differences (Le Fevre, 1961). 

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