CoMFA patent

As a logical consequence, these methods were introduced in QSAR analyses and a new discipline, 3D QSAR, was bom. The major breakthrough in this field was achieved by Cramer et al.f who in 1988 described the application of comparative molecular field analysis (CoMFA) for the evaluation of the binding properties of steroids to carrier proteins. This approach, for which interestingly a patent application was filed by Cramer and Wold, and assigned to the software company Tripos, was based primarily on the previous work of Wise et on a dynamic lattice-oriented molecular modeling system (DYLOMMS) dating... 

Cramer, R. D., Ill, Wold, S. CoMFA US patent application number. 237491, August 1988. 

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