Combining Different Types of Catalysis

MCRs are not restricted to the use of only one type of catalysis. Combining different types of activation facUitates the synthesis of compounds that are difficult to obtain when 

SCHEME 1.1 Biocatalyzed synthesis of isoindolo[2,l-a]quinazolines carried out by Raval and coworkers using baker s yeast as the catalyst [45a]. 

SCHEME 1.2 Cocatalyzed MCR using a metal catalyst and an organocatalyst along with the proposed mechanism [46]. 

---