Collagen, stabilization

Vitagliano, L., Berisio, R., Mastrangelo, A., Mazzarella, L., Zagari, A. Preferred proline puckerings in cis and trans peptide groups implications for collagen stability. Protein Sci. 2001, 10, 2627-32. 

De Rider, M. L., Wilkens, S. J., Waddell, M. J., Bretcher, L. E., Weinhold, F., Raines, R. T., and Markely, J. L. (2002). Collagen stability Insights from NMR spectroscopic and hybrid density functional computational investigations of the effect of electronegative substituents on prolyl ring conformations. J. Am. Chem. Soc. 124, 2497-2505. 

Stetefeld,J., Frank, S.,Jenny, M., Schulthess, T., Kammerer, R. A., Boudko, S., Landwehr, R., Okuyama, K., and Engel, J. (2003). Collagen stabilization at atomic level Crystal structure of designed (GlyProPro o-foldon. Structure 11, 339-346. 

Pro-Pro- repeat is shown in Figure 9-22. Hydroxyproline units are formed by adding a hydroxyl group, -OH, to proiine after thej collagen chain is built. This reaction requires 1 vitamin C, which our bodies cannot make. Hydroxyproline is critical for collagen stability, so if we don t get enough vitamin C iii j our diet, the results can be disastrous. (You get scurvy, which initially results in loss of teeth and easy bruising, because your body can t repair the wear-and-tear of everyday life.)... 

Collagen Stability Revealed Using Fluorine Substitution... 

Hodges JA, Raines RT (2003) Stereoelectronic effects on collagen stability the dichotomy of 4-fluoroproline diastereomers. J Am Chem Soc 125 9262-9263... 

Improta R, Mele F, Crescenzi O, Benzi C, Barone V (2002) Understanding the role of stereoelectronic effects in determining collagen stability a quantum mechanical/molecular mechanical study of (proline-proline-glycine) polypeptides. J Am Chem Soc 124 7857-7865... 

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