Collagen-Induced Signal Transduction

Collagen signals through the same pathway as that of immune receptors. It induces phosphorylation on tyrosine on Fc receptor y-chain (FcRy), the non-receptor tyrosine kinase Syk and phospholipase Cy2 (PLCy2) . [Pg.90]

Syk assembles into signalling complex via interaction between its tandem Src biology 2 (SH2) domains and the tyrosine-phosphorylated immuno receptor tyrosine-based activation motif (ITAM) present in the FcRy. The FcRy and Syk are essential for activation of mouse platelets by collagen . [Pg.90]

Convulxin, anti-GPVI F(ab)j and CRP-XL while cross-linking GPVI induce signal transduction in part like collagen - . [Pg.90]

The role of a P, in signalling is a subject of controversial discussion. Whereas some authors think that the role of OjP, is in primary attachment rather than in subsequent [Pg.90]

The questions of whether ttjP, integrin has to be activated to bind to collagen and how OjP, GPVI/FcRy and possible other collagen receptors cross-talk and interact have still to be clarified. [Pg.91]

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