Statins Colchicine

Oral colchicine causes dose-dependent GI adverse effects (nausea, vomiting, and diarrhea) in 50% to 80% of patients before relief of the attack. Non-GI adverse effects include neutropenia and axonal neuromyopathy, which may be worsened in patients taking other myopathic drugs (e.g., statins) or in those with renal insufficiency. Colchicine should not be used concurrently with macrolide antibiotics (especially clarithromycin) because reduced biliary excretion may lead to increased plasma colchicine levels and agranulocytosis. 

Interactions of statins with colchicine have been reported. 

Three case reports describe myopathy or rhabdomyolysis in patients given colchicine with fluvastatin, pravastatin or simvastatin. It seems possible that this interaction could occur with colchicine and any statin. 

Neuromuscular fimction Colchicine-induced myopathy can present with fatigue as the only clinical manifestation [59 ]. Coadministration with statins may increase the risk [60 ]. 

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