Colchicine molecular targets

Since the discovery of the therapeutic potential of tubulin targeting drugs, there has been a demand for structural information at the molecular level about the binding pose of the small-molecule ligands, very much needed by the medicinal chemists for the rational design of novel derivatives. Even nowadays, near-atomic resolution structures are available only for a few tubulin binders, namely, the EC-derived structures of the MT-stabilizers PTX [11] and EpoA [26], and the X-ray structures of complexes of tubulin/RB3-SLD with the MT-destabilizers colchicine [12] and vinblastine [13]. 

Molecular Modeling on Compounds Targeting the Colchicine Binding Site... 

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