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Cohens Inhibitor-insensitive p38 Mutants

In the following paragraph, we describe the development of the technology, based on its first example, the kinase p38a. [Pg.179]

This was the first time that a drug-insensitive protein kinase was used for the purpose of drug target validation. Eyers et al. also discussed the general applicability to the study of other protein kinases [50], as is described in the next section. [Pg.179]




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Cohen

Insensitive

Insensitivity

Mutants, inhibitor-insensitive

P38 inhibitors

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