Coenzyme Q Solution

Add and dissolve item 6 after cooling to room temperature. 

For 125 mg dose, adjust with sucrose the final quantity. 

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A new synthetic route to alkyl-substituted quinones has relied on the photochemical reaction of 2,3-dichloro-l,4-naphthoquinone with a thiophene derivative (77CL851). Irradiation of a benzene solution of the quinone and thiophene by a high pressure mercury lamp gave photoadduct (295) in 56% yield. Desulfurization of this compound over Raney nickel (W-7) gave the 2-butyl-1,4-naphthoquinone derivative (296 Scheme 62). Alkyl-substituted quinones such as coenzyme Q and vitamin K, compounds of important biological activity, could possibly be prepared through such methodology. 

The solubility properties of coenzyme Q constitute the basis for its purification. The coenzyme can be extracted with heptane or isooctane, then treated with an alkaline solution containing pure alcohol, and after chromatographic analysis on aluminum columns, it can be crystallized from ethanol or methanol. Samples obtained by such procedures all have the same characteristics on silicon-treated paper and present identical visible and infrared spectra as well as identical coenzyme activities. 

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