Codons definition

The use of synthetic trinucleotides as building blocks would obviate the problems of stop codons or other unwanted amino acids turning up randomly in hypervariable sequences, and would indeed allow the predetermined definition of amino acid codon frequency bias. This has been demonstrated by Glaser et al. [97] for phage-display library construction see also Ref. 98 for a review of current DNA synthesis technology. 

As a general principle, translation is the step in which the nucleotide sequence of messenger RNA is translated into a definite amino-acid sequence, using the adaptor transfer RNAs decoding units. As stated before, the recognition mechanism between messenger RNA and transfer RNAs is of the codon-anti-codon type. 

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