Coding potential

Krahn, J. M., Beard, W. A., Miller, H., Grollman, A. P., and Wilson, S. H. (2003). Structure of DNA polymerase fl with the mutagenic DNA lesion 8-oxodeoxyguanine reveals structural insights into its coding potential. Structure 11, 121-127. 

L.G. Brieba et al., Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase. EMBO J. 23, 3452-3461 (2004)... 

While considering the presence of U in DNA, it is relevant to point out that this base can also arise in DNA by its misincorporation (instead of T) during normal DNA replication as a consequence of the existence of a small pool of dUTP (1). Not unexpectedly, perturbations that increase the pool size of dUTP relative to that of TTP promote this misincorporation (1). However, the biologic consequences of A U mispairs in DNA are limited because such base pairs have the same coding potential as A T pairs (1). 

Paralogous Genes Can Diverge in Coding Potential and Expression Pattern 41... 

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