Cobalamin unsaturated carbonyl compounds

The cobalt(I) cobalamin catalyzed reduction of a-methyl-a,P-unsaturated carbonyl compounds produces the corresponding saturated derivatives having an (5)-configuration at the a-carbon (Scheme 81) 424 highest enantiomeric excess (33%) is exhibited by the (Z)-configurated methyl ketone. The... 

It was found empirically that well-pronounced catalytic effects can be observed in the presence of nitrogen-containing heterocyclic compounds (e.g. pyridine or quinoline derivatives, a number of alkaloids, cobalamin etc.). However, aliphatic nitrogen compounds (e.g. aminoacids), carbonyl compounds, oxygen-containing heterocyclic substances, unsaturated molecules or even hydrocarbons, e.g. azulenes also give catalytic waves. 

---

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

---