Coactivator-binding groove

Wang Y, et al. A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta. Proc. Natl. Acad. Sci. U.S.A. 2006 103 9908-9911. 

FIGURE 5.6 (b) Antagonist-induced deactivation of the mouse CAR LBD. The helices H10, HI 1 (yellow), Hx (invisible), and AF-2 (red) adopt a conformation that disrupts the coactivator binding groove and deactivates the receptor. 

Figure 31.25. Coactivator-Nuclear Hormoue Receptor Interactions. The structure of a complex between the ligand-binding domain of the estrogen receptor with estradiol bound and a peptide from a coactivator reveals that the Leu-X-X-Leu-Leu (LXXLL) sequence forms a helix that binds in a groove on the surface of the ligand-binding domain.

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