Co-dehydrogenases

CO Dehydrogenase, also incorporating Fe and catalysing the oxidation of CO to CO2. The attachment of CO to a nickel centre coordinated to perhaps four 5-donors is postulated. 

NICKEL-IRON-SULFUR ACTIVE SITES HYDROGENASE AND CO DEHYDROGENASE... 

In contrast to the abundance of Fe-proteins, there are only six known nickel-containing enzymes hydrogenase, CO dehydrogenase (CODA), acetyl-CoA synthase (ACS), superoxide dismutase, urease, and S-methyl-CoM methylreductase. Among these enzymes, it exists in very diverse environments, including a dinickel site (urease), a Ni-Fe heterobinuclear site (hydrogenase), a Ni-Fe4S4 heterometallic... 

Fig. 11. Active sites and reactions of the bifunctional CODH/ACS. For synthesis of acetyl-CoA, two electrons are transferred from external electron donors to Cluster B of the CODH subunit. Electrons are relayed to Cluster C which reduces CO2 to CO. The CO is proposed to be channeled to Cluster A of the ACS subunit to form a metal-CO adduct that combines with the methyl group of the CFeSP and CoA to form acetyl-CoA. For utilization of acetyl-CoA, these reactions are reversed. The abbreviations are CODH, CO dehydrogenase ACS, acetyl-CoA synthase CFeSP, the corrinoid iron-sulfur protein CoA, Coenzyme A.

Dobbek H, L Gremer, R Kiefersauer, R Huber, O Meyer (2002) Catalysis at a dinuclear [CuSMo(=0)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution. Proc Natl Acad Sci USA 99 15971-15976. 

Parkin A, Seravalh J, Vincent KA, Ragsdale SW, Armstrong FA. 2007. Rapid and efficient elec-trocatal3tic CO2/CO interconversions by Carboxydothermus hydrogenoformans CO dehydrogenase I on an electrode. J Am Chem Soc 129 10328-10329. 

Hydrogenase and CO Dehydrogenase Juan C. Fontecilla-Camps and Stephen W. Ragsdale... 

Three of the eight Ni proteins that are known as hydrogenase, CO dehydrogenase (CODH), and acetylCoA synthase (ACS), are Ni-Fe-S proteins. Hydrogenases play an important role in microbial energy metabolism by catalysing the reversible oxidation of hydrogen ... 

Rhodospiriiium rubrum [NiFe] hydrogenase Membrane-bound H2 production component of the during CO dehydrogenase CO oxidation complex 0,0.2 18... 

The CO dehydrogenase/acetyl-CoA synthase (Cdh) complex cleaves the C-C and C-S bonds in the acetyl moiety of acetyl-CoA, oxidizes the car-... 

Murakami E, Ragsdale SW. 2000. Evidence for intersnbnnit communication during acetyl-CoA cleavage by the multienzyme CO dehydrogenase/acetyl-CoA synthase complex from Methanosarcina thermophila. Evidence that the beta subunit catalyzes C-C and C-S bond cleavage. J Biol Chem 275 4699-707. 

Clostridium peifringens ferredoxin, 38 261 Clostridium thermoaceticum, 32 326 carboxylic acid reductase, 40 73 CO dehydrogenase, 38 362 formate dehydrogenase, 40 71-72 CISCN, 33 81... 

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