Clozapine chromatogram

Figure 6.12. Base peak chromatograms obtained from 75-/xL urine samples spiked with clozapine metabolites using LTQ-FTICR. (a,b) Samples spiked with oxidative metabolites, where (a) was from unprocessed data and (b) from MDF-processed data. (c,d) Samples spiked with GSH metabolites, where (c) was from unprocessed data and (dj from MDF-processed data. The MDF settings were 0.04 Da in mass defect dimension and 50 Da around the parent or the parent-plus-GSH mass, respectively.

Figure 6.36 Representative LC/MS/MS SRM chromatograms obtained from the analysis of an extract of a 50pg/mL calibration standard. (A) Chromatogram for the m/z 410 precursor to m/z 120 product ion of clozapine. (.B) Chromatogram of the m/z 416 precursor to m/z 126 product ion of 13C6-clozapine [internal standard], (Reprinted with permission from Dear et al., 1998. Copyright 1998 Elsevier.)...

Selected ion monitoring chromatograms of clozapine standard and hair sample extract using the masses 243 and 256. 

Flupentixol and haloperidol (antipsychotics) were extracted fiom serum and eluted on a 40°C cyanopropyl column (A = 254 nm) using a 92/11/3 acetonitrile/ methanol/water (0.1 M ammonium acetate) with 50 pL of triethylamine added/L mobile phase [1510]. The haloperidol eluted between the cis- and rraws-flupentixol peaks at about 10 min. Calibration curves were constructed from 0.5 to 20 ng/mL. Detection limits were reported as 0.1 ng/m (S/N = 3). Interestingly, in addition to the above analytes, the chromatogram also showed benpetdiol, clozapine, levo-mepromazine, chlorprothixene, olanzapine, respirodone, fluphenazinesulfoxide, melperone, and perazine, all of which are at least partially resolved from one... 

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