Clostridium Binding component

Another subfamily of ADP-iibosylating toxins modifies G-actin (at Argl77), thereby inhibiting actin polymerization. Members of this family are, for example, C. botulinum C2 toxin and Clostridium perfringens iota toxin. These toxins are binary in structure. They consist of an enzyme component and a separate binding component, which is structurally related to the binding component of anthrax toxin [3]. 

Blocker, D., Bachmeyer, C., Benz, R., Aktories, K. and Barth, H., Channel formation by the binding component of Clostridium botulinum C2 toxin glutamate 307 of C2II affects channel properties in vitro and pH-dependent C2I translocation in vivo, Biochem., 42, 5368-5377, 2003. 

Dallas, S. D., and Rolfe, R. D. (1998). Binding of Clostridium difficile toxin A to human milk secretory component. /. Med. Microbiol. 47, 879-888. 

Fujinaga Y, Inoue K, Nomura T, Sasaki J, Marvaud 1C et al. (2000) Identification and characterization of functional subunits of Clostridium botulinum type a progenitor toxin involved in binding to intestinal microvilli and erythrocytes. FEBS Lett 467 179-83 Fujita R, Fujinaga Y, Inoue K, Nakajima H, Kumon H et al. (1995) Molecular characterization of two forms of nontoxic-nonhemagglutinin components of Clostridium botulinum type a progenitor toxins. FEBS Lett 376 41 4... 

Bi2-binding domains of methionine synthase, Science 266, 1669-1674. Marsh, E. N. G., Holloway, D. E. (1992) Cloning and sequencing of glutamate mutase component S from Clostridium tetanomorphum, FEES Lett. 310, 167-170. 

---