Clorazepate Smoking

Smoking cessation, with or without nicotine substitutes, may alter response to concomitant medication in ex-smokers. Smoking may affect alcohol, benzodiazepines, beta-adrenergic blockers, caffeine, clozapine, fluvoxamine, olanzapine, tacrine, theophylline, clorazepate, lidocaine (oral), estradiol, flecanide, imipramine, heparin, insulin, mexiletine, opioids, propranolol, catecholamines, and cortisol. 

A 20-year-old man with no previous movement disorders, who had smoked marijuana for 4 years was given risperidone 9 mg/day and clorazepate 10-20 mg/day for paranoid schizophrenia. After 4 weeks he started... 

Ochs HR, Greenblatt DJ, Locniskar A, Weinbrenner J. Influence of jropranolol coadministration or cigarette smoking on the kinetics of desmethyldiazepam followii intravenous clorazepate. Klin Wochenschr( 9Z6) 64,1217-21. 

Some studies have suggested that smoking does not affect the pharmacokinetics of diazepam, chlordiazepoxide, clorazepate, lorazepam, ... 

Norman TR, Fulton A, Burrows GD, Maguire KP. Pharmacokinetics of N-desmethyldi-azepam after a single oral dose of clorazepate the effect of smoking. EurJ Clin Pharmacol (1981)21,229-33,... 

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