Omeprazole Clorazepate

Two elderly patients, both smokers, taking triazolam with lorazepam or flurazepam, developed gait disturbances when they were given omeprazole 20 mg daily. They rapidly recovered when eitherthe benzodiazepines or the omeprazole were stopped. A brief report deseribes a patient taking omeprazole who became wobbly and sedated by small, unspeeified doses of diazepam, and another report describes a patient who developed toxie levels of nordiazepam and remained unconscious for 13 days after reeeiv-ing a high dose of clorazepate (1500 mg over about 29 hours) and omeprazole 80 mg daily. ... 

Konrad A. FYotracted episc of reduced consciousness following co-medicadon with omeprazole and clorazepate. Clin Drug Invest (2000) 19,307-11. 

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