Rosuvastatin Clopidogrel

The authors of a major review of rosuvastatin concluded that its adverse reaction profile resembles that of other commonly used statins [34 ]. Increments in fiver enzymes are in most cases minor and of minimal concern, renal dysfunction is quite uncommon, myopathy is unusual, and rhab-domyolysis is rare. Interactions with other drugs are fisted but no new information given. Combinations with fenofibrate, omega-3 fatty acids, ezetimibe, rifampicin, and clopidogrel appear to be safe. 

Riondino S, Petrini N, Donato L, Torremeo C, Tanzilli G, Pulcinelli FM, Barilla F. Effects of rosuvastatin on platelet inhibition by clopidogrel in cardiovascular patients. J Thromb Thrombolysis 2009 28 151-5. 

Malmstrom RE, Ostergren J, Jorgensen L, Hjemdahl P. Influence of statin treatment on platelet inhibition by clopidogrel—a randomized comparison of rosuvastatin, ator-vastatin and simvastatin co-treatment. J Intern Med 2009 266 457-66. 

In patients with coronary artery disease who took part in a double-blind comparison of atorvastatin 20-80 mg/day ( = 22) and rosuvastatin 10-40 mg/day ( = 24), the platelet inhibitory effects of clopidogrel were not altered [176 ]. 

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