Tiapride Clonazepam

Neuroleptic malignant syndrome. Three cases of neuroleptic malignant syndrome have been reported following the use of diazepam with risperidone, clorazepate with zuclopenthixol and tiapride with clonazepam. In 2 cases this followed the abrupt withdrawal of long-term benzodiazepines. All 3 patients recovered, one without any treatment. These reports are isolated and unexplained. There appears to be no clear reason for avoiding concurrent use, but it should be well monitored. 

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